Is sodium bicarbonate powder safe for subgingival use?

Sodium bicarbonate is not among the powders evaluated for subgingival use in the indexed literature. The systematic reviews and meta-analyses in the context focus specifically on glycine, erythritol, and trehalose as the powders studied for subgingival air-polishing ^[1][2][3]. Glycine has a particle size of 25–65 μm, trehalose 25–35 μm, and erythritol 14 μm, and all three are described as having no significant adverse events in subgingival applications ^[2]. Sodium bicarbonate, which has a much larger and more abrasive particle size, is not discussed in the subgingival context in any of the indexed passages, so no evidence-based statement about its subgingival safety can be drawn from this literature. For that specific question, The indexed literature does not directly address this.