Research at Preventio Hub
Pre-registered evidence-synthesis protocols, systematic reviews, and a public registry you can scrutinise.
Most dental-prophylaxis marketing runs on cherry-picked studies. Our job is the opposite: define the question, lock the methodology, run the search, and publish what the evidence actually supports — including when the answer is "not enough data to say".
Everything we commit to synthesising is pre-registered in our public Evidence Registry before the underlying search is run. The protocol is frozen, the methodology is locked, and the date is independently verifiable. If the final synthesis deviates from the protocol, we record the deviation as an amendment — never retroactively conceal it.
Evidence Registry
A public, timestamped ledger of the evidence-synthesis protocols we've committed to execute. Our self-hosted substitute for PROSPERO — functionally equivalent for readers, compatible with our editorial anonymity.
View registry →Erythritol vs Glycine Air Polishing in Peri-Implantitis
A registered systematic review and meta-analysis protocol comparing erythritol- and glycine-based air polishing powders as adjuncts to non-surgical peri-implantitis management. Includes a pre-specified industry-sponsorship sensitivity analysis.
Read the protocol →How we work
- Pre-registration before search. The protocol is published with a dated URL before any database query is run. This prevents moving goalposts after seeing the data.
- PRISMA 2020 reporting. Every systematic review follows the PRISMA 2020 standard for transparent, replicable synthesis.
- Independent risk-of-bias assessment. Cochrane RoB 2 for randomised trials, ROBINS-I for non-randomised studies. Assessed blind to author, journal, and funding source where feasible.
- GRADE for certainty of evidence. Every key outcome is rated high, moderate, low, or very low — and the rating is justified, not asserted.
- Pre-specified sensitivity analyses for industry funding. Trials are classified by sponsorship tier (independent, in-kind, industry-funded, author on payroll). Pooled effects are recomputed excluding industry-funded studies. If the effect direction changes, we say so.
- Amendments, not rewrites. If a protocol changes mid-review, the change is documented with timestamp and rationale on the protocol page. Version history is preserved.
- Honest gaps. If the evidence is too thin, too biased, or too heterogeneous to support a pooled estimate, we narrate the gap rather than invent a number.